摘自：European Review for Medical and Pharmacological Sciences

作者：B.-L. ZHANG, L.-J. WANG, L. SUN, H.-L. ZHANG, X.-M. WU1,Y. SUN, F. DENG, Y. ZHANG, Y.-Y. CHENG, J.-C. FENG

Abstract. – OBJECTIVE: Tuberous sclerosis complex (TSC) is the second most common phakomatosis and is characterized by the formation of benign hamartomas and low-grade neoplasms in multiple organ systems. In this study,our objective here was to explore the interaction
and crosstalk between pathways in response to tuberous sclerosis complex.
MATERIALS AND METHODS:We enriched the significant pathways and made the crosstalk analysis of the significant pathways.
RESULTS: The results showed that ECM-receptor interaction was a significant pathway in TSC.
In addition, insulin-signaling and mTOR signaling also have been identified involved in TSC here,
which have been well characterized. Further analysis indicated that there was a crosstalk between
ECM-receptor interaction and antigen processing and presentation, ECM-receptor interaction and apoptosis, and leishmaniasis-oxidative phosphorylation-pancreatic cancer. In this study, a network-based approach was used to analyze the crosstalk among TSC related pathways. The crosstalk of pathways is found and analyzed using the PPI datasets and expression profiles.
CONCLUSIONS: Our work showed that comprehensive and system-wide analysis could provide
evidence for TSC pathway and complement the traditional component-based approaches.The crosstalk identified might provide new alternative insights into the TSC pathology, which may contribute to the development of novel therapeutic targets for TSC.
Key Words:
ECM-receptor interaction, Pathway crosstalk, Tuberous sclerosis complex, Leishmaniasis-oxidative phosphorylation-pancreatic cancer, Benign hamartomas.

Identifying significant crosstalk of pathways in tuberous sclerosis complex.pdf